Overview
Selank is a synthetic heptapeptide analog of tuftsin with demonstrated anxiolytic and anti-asthenic properties. The peptide consists of the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro and has been studied extensively in clinical trials.
Quick Start Summary
– Reconstitution: Add 3.0 mL bacteriostatic water to create ~3.33 mg/mL concentration
– Daily dose range: 300–500 mcg via subcutaneous injection
– Measurement: 1 unit on U-100 insulin syringe ≈ 33.3 mcg
– Frequency: Once daily
– Cycling: 4 weeks on, 4 weeks off (or 5 days per week with 2-day breaks)
Dosing Protocol
Gradual Titration Schedule
| Week | Daily Dose | Units (per injection) |
|---|---|---|
| 1–2 | 300 mcg | 9 units (0.09 mL) |
| 3–4 | 500 mcg | 15 units (0.15 mL) |
Administration: Inject once daily subcutaneously. Some practitioners recommend 5 days weekly with 2-day breaks to prevent tachyphylaxis.
Reconstitution Instructions
1. Draw 3.0 mL bacteriostatic water with sterile syringe
2. Inject slowly down vial wall to avoid foaming
3. Gently swirl/roll until dissolved (avoid vigorous shaking)
4. Label vial and refrigerate at 2–8°C, protected from light
Storage Guidelines
Lyophilized form: Store at −20°C (−4°F) for long-term stability, or 2–8°C for shorter periods
Reconstituted solution: Refrigerate at 2–8°C; stable approximately 1 month with minimal potency loss. Avoid repeated freeze–thaw cycles. Allow vials to reach room temperature before opening to reduce condensation.
Supplies Needed (8–16 Week Protocol)
Peptide Vials
– 8 weeks: ~2 vials
– 12 weeks: ~4 vials
– 16 weeks: ~5 vials
Insulin Syringes (U-100)
– 8 weeks: 56 syringes
– 12 weeks: 84 syringes
– 16 weeks: 112 syringes
Bacteriostatic Water (10 mL bottles)
– 8 weeks (2 vials): 1 bottle
– 12 weeks (4 vials): 2 bottles
– 16 weeks (5 vials): 2 bottles
Alcohol Swabs
– 8 weeks: 2 × 100-count boxes
– 12 weeks: 2 × 100-count boxes
– 16 weeks: 3 × 100-count boxes
How Selank Works
“In Russian clinical trials for anxiety disorders and neurasthenia, intranasal Selank produced anxiolytic effects comparable to benzodiazepines while providing anti-asthenic benefits without sedative effects or dependence potential.”
Preclinical primate studies demonstrated that intranasal administration eliminated fear and anxiety behaviors with long-term stabilizing effects. Rodent studies confirmed anxiolytic efficacy comparable to classical tranquilizers. While most published human data used intranasal dosing, subcutaneous administration has shown effectiveness in research settings with consistent absorption.
Injection Technique
– Wash hands and prepare clean work surface
– Clean vial stopper with alcohol swab and allow to dry
– Draw appropriate volume into sterile insulin syringe; remove air bubbles
– Clean injection site with fresh alcohol swab; allow to dry
– Pinch skinfold of subcutaneous tissue; insert needle at 90° angle
– Do not aspirate for subcutaneous injections
– Inject slowly and steadily
– Withdraw needle straight out; apply gentle pressure if bleeding occurs
– Dispose of syringe immediately in sharps container (never reuse)
– Rotate sites systematically: abdomen (2+ inches from navel), thighs, upper arms
Important Safety Notes
– Use new sterile insulin syringes for each injection
– Rotate injection sites to reduce local irritation and prevent tissue changes
– Document daily dose, timing, and site rotation throughout protocol
– Multi-use bacteriostatic water vials should be dated and discarded within 28 days of opening
Lifestyle Considerations
– Maintain 7–9 hours of quality sleep nightly
– Incorporate regular physical activity (aerobic and resistance training)
– Practice stress-management techniques (mindfulness, meditation, breathwork)
– Support nutritional status with adequate protein, omega-3s, and micronutrients
– Minimize alcohol and stimulant use
Potential Benefits
– Produces anxiolytic effects comparable to benzodiazepines without sedation or dependence risk
– Provides anti-asthenic (energy-boosting) benefits alongside anxiety reduction
– Induces lasting neurobehavioral changes with long-term stabilizing effects
– Generally well tolerated; 14-day continuous course demonstrated safety and efficacy in human trials
– Lacks sedative side effects, allowing daytime use without impairment
– Explored at higher doses for opioid withdrawal symptom attenuation
Possible Side Effects
– Occasional mild injection-site reactions (redness, minor irritation)
– Proper site rotation minimizes local reactions
– Well-tolerated at studied doses
Disclaimer
This content is for educational and research purposes only and does not constitute medical advice, diagnosis, or treatment. Selank is for research use only and not intended for human consumption. Always consult qualified healthcare professionals before considering any peptide therapy.