Overview
Vesugen, also known as KED, is a tripeptide bioregulator created at the Saint Petersburg Institute of Bioregulation and Gerontology. Research suggests it “may support vascular endothelial cell proliferation through epigenetic regulation of Ki-67 gene expression.”
What It Is
Vesugen comprises three amino acids associated with vascular wall proteins. The peptide is theorized to interact with gene promoter regions, potentially influencing epigenetic regulation and cell division mechanisms related to vascular health.
Reconstitution Instructions
Standard Approach (3 mL dilution):
– Add 3.0 mL bacteriostatic water to the 20mg vial
– Results in approximately 6.67 mg/mL concentration
– Dissolve by gently swirling (avoid shaking or foaming)
– Label and refrigerate at 2–8°C (35.6–46.4°F)
– Protect from light
Storage:
– Lyophilized: −20°C (−4°F) in dry, dark conditions
– Reconstituted: 2–8°C (35.6–46.4°F); avoid freeze-thaw cycles
Dosing Protocol
Gradual Titration Schedule:
| Week | Daily Dose | Syringe Measurement |
|---|---|---|
| 1 | 500 mcg | 7.5 units (0.075 mL) |
| 2 | 1000 mcg | 15 units (0.15 mL) |
| 3 | 1500 mcg | 22.5 units (0.225 mL) |
| 4–8+ | 1500–2000 mcg | 22.5–30 units (0.225–0.30 mL) |
Administration:
– Subcutaneous injection once daily
– Rotate injection sites (abdomen, thighs, upper arms)
– Cycle length: 8–12 weeks (optional extension to 16 weeks)
Injection Technique
– Clean vial stopper and injection site with alcohol; allow to dry
– Pinch a skinfold; insert needle at 45–90° angle into subcutaneous tissue
– Do not aspirate for subcutaneous injections
– Inject slowly and steadily
– Rotate sites systematically to avoid lipohypertrophy
Supplies Needed (8-week cycle example)
– Vesugen vials: 5 vials (20mg each)
– U-100 insulin syringes: 56 syringes
– Bacteriostatic water: 2 × 10mL bottles
– Alcohol swabs: 2 × 100-count boxes
Potential Benefits
Research indicates Vesugen may:
– Support vascular endothelial cell proliferation and renewal
– Exhibit neuroprotective properties in CNS applications
– Restore synaptic plasticity in Alzheimer’s disease models
– Generally demonstrate good tolerability in studies
Side Effects
Occasional mild injection-site reactions (redness or itching) may occur with subcutaneous administration. Generally well-tolerated in reported studies.
Lifestyle Considerations
– Maintain a heart-healthy diet rich in antioxidants and omega-3 fatty acids
– Incorporate regular cardiovascular exercise
– Prioritize quality sleep and stress management
Important Notes
– For research purposes only; not for human consumption
– This is educational content, not medical advice
– Use sterile, new insulin syringes; dispose in sharps container
– Document daily doses and site rotation for consistency
– Consult qualified healthcare professionals before beginning any protocol
Disclaimer: All information is for research and educational purposes only and is not intended to diagnose, treat, cure, or prevent disease.